Exchange-dependent relaxation in the rotating frame for slow and intermediate exchange - modeling off-resonant spin-lock and chemical exchange saturation transfer
نویسندگان
چکیده
منابع مشابه
Spin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons.
Chemical exchange saturation transfer (CEST) and spin-locking (SL) experiments were both able to probe the exchange process between protons of nonequivalent chemical environments. To compare the characteristics of the CEST and SL approaches in the study of chemical exchange effects, we performed CEST and SL experiments at varied pH and concentrated metabolite phantoms with exchangeable amide, a...
متن کاملAnalytical determination of the chemical exchange saturation transfer (CEST) contrast in molecular magnetic resonance imaging
Magnetic resonance based on molecular imaging allows tracing contrast agents thereby facilitating early diagnosis of diseases in a non-invasive fashion that enhances the soft tissue with high spatial resolution. Recently, the exchange of protons between the contrast agent and water, known as the chemical exchange saturation transfer (CEST) effect, has been measured by applying a suitable pulse ...
متن کاملEvaluating exchange processes in the human brain: magnetization transfer vs adiabatic rotating frame relaxation methods
Introduction Exchange processes of bulk water protons with the protons contained in the macromolecules of tissue can be investigated with magnetization transfer (MT) experiments, which rely on saturating the “solid” pool by placing a preparation pulse (typically a continuous-wave (CW) pulse) several kHz offresonance from water [1]. Since the frequency of the off-resonance pulse does not have a ...
متن کاملpCEST: Positive contrast using Chemical Exchange Saturation Transfer.
Chemical Exchange Saturation Transfer (CEST) contrast utilizes selective pre-saturation of a small pool of exchanging protons and subsequent detection of the decrease in bulk water signal. The CEST contrast is negative and requires detection of small signal change in the presence of a strong background signal. Here we develop a Positive CEST (pCEST) detection scheme utilizing the analogous natu...
متن کاملResponsive paramagnetic chemical exchange saturation transfer MRI contrast agents
Molecular imaging research has shown great potential to assess the molecular compositions of tissues and provide critical information for clinical diagnoses [1]. These noninvasive assessments of molecular compositions may provide earlier diagnoses of pathologies, may predict therapeutic effects before the therapy is initiated and may provide earlier assessments of therapeutic effects soon after...
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ژورنال
عنوان ژورنال: NMR in Biomedicine
سال: 2012
ISSN: 0952-3480
DOI: 10.1002/nbm.2887